Dr. Malte Gersch’s research focuses on biochemical processes in intracellular interaction, where the protein ubiquitin marks other proteins to control their deterioration, transport or activity– rather like a “molecular Post-it”. In the new UbiPRO task, he will study the catalytic activities of unique enzymes called deubiquitinases (DUBs). For this function, Gersch will establish a chemoproteomic platform for analyzing the activity of these enzymes. With the aid of novel, chemically customized ubiquitin probes, he will reproduce intricate polyubiquitin structures and decipher the mechanisms by which Calls recognize and process specific signals. The task combines techniques from protein chemistry, chemoproteomics and structural biology, and aims to get brand-new insights into the policy of the ubiquitin system– possibly leading to a much better understanding of disease systems and the advancement of therapeutic strategies.
About Dr. Malte Gersch
Dr. Malte Gersch studied chemistry and biochemistry at LMU Munich. A research study stay at Stanford University School of Medicine awakened his interest in chemical biology, and he consequently completed his doctoral degree under the supervision of Professor Stephan Sieber at the Technical University of Munich, where he conducted research study on the function and inhibition of the bacterial proteasome ClpP. During his postdoctoral stay at Professor David Komander’s lab in Cambridge, UK, he concentrated on the policy and structure of human deubiquitinases. He moved to Dortmund at the end of 2018, where he heads an Emmy Noether independent junior research group at the Department of Chemistry and Chemical Biology of TU Dortmund University and works at the Chemical Genomics Center (CGC) at the Max Planck Institute for Molecular Physiology. Dr. Malte Gersch has gotten numerous awards for his research, including the Hans Fischer Prize, the Friedrich Weygand Prize, the Emil Erlenmeyer Medal and the ORCHEM Reward.
About the ERC Consolidator Grant
With the ERC Consolidator Grant, the European Research study Council supports excellent scientists who have developed an exceptional clinical profile within twelve years of finishing their postgraduate degree. This private financing gives grant holders the chance to carry out particularly innovative and pioneering work in the lives sciences.
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